Management Diets with Functional Analogue Rice control TCF7L2 Expression of Rattus norvegicus 1769, Berkenhout Model Type 2 Diabetes Mellitus
Penulis/Author
GRAVINDA WIDYASWARA (1); apt. Rumiyati, S.Si., M.Si., Ph.D. (2); Prof. Dr. Yekti Asih Purwestri, S.Si., M.Si. (3)
Tanggal/Date
1 2021
Kata Kunci/Keyword
Abstrak/Abstract
Abstract
Type 2 DM is strongly related to TCF7L2 gene that
plays a role in the insulin secretion which can be
controlled by consuming low glycemic index foods such
as functional analogue rice Formula 31 (F31). This
study was to determine the effect of functional analogue
rice F31 based on mocaf, corn, lebui beans and
seaweed on TCF7L2 gene expression in rats model of
type 2 DM. Male and female rats were induced by
streptozotocin at the age of 2 d after birth, then grouped
into 4 treatments namely normal BR1 feed (control
group), normal functional analogue rice F31, type 2
DM BR1 feed and type 2 DM functional analogue rice
F31. TCF7L2 expression was observed through RNA
isolation from pancreatic organ, cDNA synthesis and
RT-qPCR analysis.
The expression of TCF7L2 gene in normal male
functional analogue rice F31 and type 2 DM male
functional analogue rice F31 was 2.64 times and 1.35
times higher than control respectively. The expression
of TCF7L2 in normal female functional analogue rice
F31 was 22.01 times higher than control. Management
diet with functional analogue rice F31 generally can
increase the expression of TCF7L2 gene compared to
BR1 feed in rats model of type 2 DM.
Keywords: Functional analogue rice F31, management diet,
nutrigenomics, type 2 DM, TCF7L2 gene.
Rumpun Ilmu
Biologi (dan Bioteknologi Umum)
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Widyaswara& Yekti.pdf
[PAK] Full Dokumen
2
30_ RJB 2021 - Lampiran 2 (Cover).pdf
Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
