| Abstrak/Abstract |
Preeclampsia leads to endothelial dysfunction and kidney injury with inflammation and fibrosis. Low-dose
acetylsalicylic acid (ASA) administration may decrease uterine artery resistance; however, its effect on the
kidney has not been elucidated yet. We performed a preeclampsia model in pregnant female Wistar rats (PE group, n=5, 150-200 grams) using L-NAME 50mg/kg of BW intraperitoneal injection on day 1-18 of
pregnancy. Low doses of ASA with dose 75 (PE+ASA75) and 125 (PE+ASA125) mg/kg body weight were
administered in preeclampsia rats in the day 10-12 day of pregnancy. The Control group was normal pregnant rats with NaCl treatment (n=5). On day 18, rats were sacrificed; kidneys were harvested, then extracted for Reverse Transcriptase-PCR (RT-PCR) of eNOS, TGF-β1, and IL-6 mRNA expression measurements.
Proteinuria and rat blood pressure were measured before termination. L-NAME injection-induced preeclampsia showed significantly higher systolic blood pressure and proteinuria in the PE group than in the control group (p<0.05). However, there were no changes in podocin and nephrin expression. In conclusion, the low dose of ASA 125mg/Kg BW ameliorates kidney inflammation and TGF-β1 expression in the rat preeclampsia model's kidney. |
