| Abstrak/Abstract |
Abstract. Hypertriglyceridemia (HTG) is high level of triglycerides in the blood and may affect in liver function. Liver is a vital
organ that has complex functions such as bile secretion, bilirubin metabolism, detoxification, a store of vitamins and
minerals. Arthrospira maxima and Chlorella vulgaris are the natural ingredients that are widely cultivated and have beneficial
nutrients such as high of amino acids, minerals, vitamins, fiber and bioactive compounds that can be hepatoprotective agent.
The purpose of this research was to determine and study the effect of Arthrospira maxima and Chlorella vulgaris as
preventive treatment on liver function of HTG rats (Rattus norvegicus Berkenhout, 1769). Twenty female Wistar rats were
divided into 5 groups randomly. The groups were control and treatment groups. The control groups were normal, HTG, and
gemfibrozil groups. The treatment groups were A.maxima and C.vulgaris groups. In this research, HTG induction in
preventive treatment by a mixture of used cooking oil (jelantah) with saturated fat (15 ml/kg.bw.). Rats of treatment groups
were HTG induction then followed by A.maxima (2500mg/kg.bw.) or C.vulgaris(2500mg/kg.bw.) treatments for 40 days. The
TG (triglyceride), ALT (Alanine aminotransferase), and bilirubin level were measured using spectrophotometric methods.
Hepatosomatic index was measured using analytical balance. The data was statistically analyzed using one way ANOVA and
followed by DMRT. The hepatocyte was qualitatively analyzed. The TG level of HTG group was significantly increase compared
with other groups (p<0.05). ALT and bilirubin levels on A.maxima and C.vulgaris group were significantly lower than HTG
group (p<0.05). Hepatosomatic index of HTG group was significantly higher than other groups (p<0.05). Observed hepatocyte
damage were swelling, pycnosis, karyorrhexis, and karyolysis. The research conclude that the increasing TG level and liver
damage can be prevented by A.maxima and C.vulgaris.
Keywords : Hypertriglyceridemia, jelantah, liver function, Arthrospira maxima, Chlorella vulgaris. |
