Karya
Judul/Title Lesser yam induces pgc-1alfa protein expression on brown adipose and skeletal muscle tissues in diabetic rats.
Penulis/Author TRI SETYAWATI (1); Dr. Dra. Prasetyastuti, Apt., M.Kes. (2) ; Prof. Dr. Dra. Sunarti, M.Kes. (3)
Tanggal/Date 2017
Kata Kunci/Keyword
Abstrak/Abstract Background: Low expression of PGC-1alfa in Diabetes Mellitus (DM) is closely related to impaired function of mitochondria. Secondary metabolites from fermented lesser yam can increase the expression of PGC-1alfa protein. Aim: This study evaluated the effect of lesser yam flour on Pgc-1alfa expression of brown adipose and skeletal muscle in diabetic rats. Method: Twenty-five male Wistar rats, divided into 5 groups: 1) normal rats, 2) diabetic rats, 3) diabetic rats with 1.25 g, 4) diabetic rats with 2.5 g, and 5) diabetic rats with lesser yam flour 5 g per day. Diabetic rats were conducted by inducing of nicotinamide and streptozotocin via intraperitoneal injection. Blood glucose levels were measured before and after administration of the lesser yam flour. After 4 weeks of treatment, the brown adipose and the skeletal muscle tissues were taken under anesthesia, and the expression of Pgc-1alfa protein was analysed by immunohistochemistry method. Results: Blood glucose levels were significantly reduced in the group of lesser yam compared to diabetic control group (P=0.001). The expression of Pgc-1alfa protein is highly expressed in both brown adipose and skeletal muscle tissues compared to diabetic control group (P=0.162; P=0.004), respectively. Conclusion: Lesser yam may improve mitochondrial function through increased the expression of Pgc-1alfa protein.
Rumpun Ilmu Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
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