Karya
Judul/Title Kinetics Study of Paracetamol Production from Para-Aminophenol and Acetic Anhydride
Penulis/Author Rifki Wahyu Kurnianto, S.T., M.Eng. (1) ; Ir. Moh. Fahrurrozi, M.Sc., Ph.D., IPU (2); Dr. Hilda Ismail, M.Si., Apt. (3); Prof. Dr.rer.nat. apt. Raden Rara Endang Lukitaningsih, S.Si., M.Si. (4); INDAH TRI NUR'AINI (5); Dr. Pudjono, SU., Apt. (6); Prof. Ir. Rochmadi, S.U., Ph.D., IPU. (7); Dr. B.S. Ari Sudarmanto, M.Si. (8); Prof. Dr. apt. Ratna Asmah Susidarti, MS. (9)
Tanggal/Date 23 2021
Kata Kunci/Keyword
Abstrak/Abstract In the last decade, Indonesia intensifies the efforts to reduce pharmaceutical imports. One of the initiatives is establishing a paracetamol production facility to start operating in 2024. Kinetics study is needed as basis to design the paracetamol reactor. This study investigated the optimal temperature, reactant mole ratio, and agitation speed in the reaction step of paracetamol production. In this study, aqueous solution of para-aminophenol was reacted with acetic anhydride. The mole ratio of para-aminophenol to acetic anhydride was varied to 1:1, 1:1.2, 1:1,5, and 1:2 while the temperature was varied to 80 oC, 90 oC, and 110 oC. However, due to uncontrolled heat of the reaction and limitation of the mixture’s boiling point, the actual reaction temperatures were 86 oC, 90 oC, and 108 oC. In addition, the agitation speed of 250 RPM and 350 RPM were also studied. Thin layer chromatography (TLC) and densitometry were used to determine the concentration of paracetamol in the reacting mixture. The optimum temperature, reactant mole ratio, and agitation speed in this study were 108 oC, 1:1.5, and 350 RPM, respectively. In addition, a reaction performed under those operating parameters gave the reaction rate constant of 1.9446 L mol-1 min-1.
Rumpun Ilmu Teknik Kimia
Bahasa Asli/Original Language English
Level Nasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1full dokumen_Kinetics Study of Paracetamol Production from ParaAminophenol and Acetic Anhydride.pdf[PAK] Full Dokumen
2SERTIFIKAT AKREDITASI JURNAL REKPROS (1).pdf
3Jurnal Rekayasa Proses_Cover.pdf[PAK] Halaman Cover
4Jurnal Rekayasa Proses_Editorial Team.pdf[PAK] Halaman Editorial
5Jurnal Rekayasa Proses_Daftar isi.pdf[PAK] Daftar Isi
6kinetic.pdf[PAK] Full Dokumen
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