| Abstrak/Abstract |
Background: There were an estimated 2.1 million breast cancer
diagnoses in 2018 worldwide, which is about 11.6% of the total cancer
incidence. A novel modality of cancer treatment based on exposure to
non-contact electric fields has been developed to reduce cancer
incidence. However, the safety of the electric field exposure was not significant.
Conclusions: The non-contact electric fields were not harmful to renal
and liver structure in tumour-induced rats. Instead, it may increase
the renal function in normal rats.
fully investigated. Therefore, the purpose of this study is to observe
the safety of the electric field exposure on renal and liver structure.
Methods: Female Sprague-Dawley rats were divided into one control
group and three treatment groups. Animals were treated with 7,12-
dimethylbenz[a]anthracene for mammary tumour induction and
exposed to non-contact electric fields individually for 10 hours a day
for three weeks. Fresh samples of the kidney and liver were collected
for observing structural damage in both organs. The two organs were
prepared for histopathological cross-sectioning using the paraffin
method and Hematoxylin & Eosin staining followed by histological
scoring using the post-examination masking method.
Results: The damages found in the kidney were the following:
thickening of Bowman capsule, karyolysis, karyorrexhis, pyknosis,
cloudy swelling, epithelial sloughing, inflammation, haemorrhage,
and congestion. The number of inflammation and haemorrhage in the
kidney structure of the placebo group was the lowest and significantly
different from the three other groups. All damages in the kidney were
also found in the liver, but each showed different levels of damage.
The damages in the kidney and liver caused by the exposure were not |
