| Abstrak/Abstract |
Jatropha curcas leaves have been proven as anti-inflammatory and antioxidant. In this study we examined the antiarthritic effects of ethanolic extract of J. curcas leaves using adjuvant induced arthritis (AIA) in rats. METHODS Male wistar rats were divided into 6 groups (n=8), consists of normal group (0.9% NaCl), control group (complete Freund’s adjuvant/CFA 1 mg/ml), Sodium diclofenac group at a dose of 6.75 mg/kg (p.o), the ethanolic extract of
J.curcas with a dose of 150 mg/kg (p.o), 300 mg/kg (p.o) and 600 mg/kg (p.o). Each group was induced by 0.2 ml CFA on day 1 and a booster injection on day 5. Extract J. curcas was administered on days 14-28. The arthritic score were determined, then analyzed using Kruskal Wallis followed by Mann Whitney test. Mobility score were analyzed using one way analysis of variance, followed by least significant difference multiple comparison test. Arthritic joint histopathology was observed on day 29.
RESULTS The results showed that the ethanolic extract of J. curcas leaves with a dose of
150 mg/kg, 300 mg/kg and 600 mg/kg significantly reduced arthritic score
(p<0.05) compared to control group (CFA). The J. curcas leaves extract with a
dose of 150 and 300 mg/kg BW decrease mobility score. Histopathology studies
showed that the J. curcas reduce edema in arthritic joints and cartilago
destruction.
CONCLUSIONS The J. curcas leaves extract had anti-arthritic by reducing arthritic score and
mobility score that should be further examined and potentially candidate as
exploited for anti-arthritic therapies. |
