Is the infection of the SARS-CoV-2 Delta variant associated with the outcomes of COVID-19 patients?
Penulis/Author
Prof. dr. Gunadi, Ph.D, Sp.BA., Subsp.DA(K) (1); dr. Mohamad Saifudin Hakim, M.Sc, Ph.D. (2); drh. Hendra Wibawa, M.Si., Ph.D. (3); MARCELLUS (4); Vivi Setiawaty (5); Slamet (6); dr. Ika Trisnawati, M.Sc., Sp.PD-KP (7); ENDAH SUPRIYATI (8); dr. Riat El Khair, M.Sc., Sp.PK. (9); dr. Kristy Iskandar, M.Sc, Ph.D, Sp.A. Subsp.Neuro.(K) (10); Afiahayati, S.Kom., M.Cs., Ph.D (11); dr. Siswanto, Sp.P(K) (12); Irene (13); dr. Nungki Anggorowati, Sp.PA(K)., Ph.D. (14); dr. Marselinus Edwin Widyanto Daniwijaya, Ph.D., Sp. MK (15); dr. Dwi Aris Agung Nugrahaningsih, M.Sc., Ph.D (16); YUNIKA PUSPA DEWI (17); Dyah Ayu Puspitarani (18); IRENE TANIA (19); KHANZA ADZKIA VUJIRA (20); MUHAMMAD BUSTON A (21); GITA CHRISTY GABRIELA (22); LAUDRIA STELLA E (23); BUNGA CITTA NIRMALA (24); ESENSI TARIAN GEOMETRI (25); ABIRAFDI AMAJIDA DARUTAMA (26); ANISA ADITYARINI K (27); Lestari (28); Sri Handayani Irianingsih (29); Siti Khoiriyah (30); Ina Lestari (31); dr. Nur Rahmi Ananda, Sp.PD-KP. (32); Prof. dr. Eggi Arguni, M.Sc., Ph.D., Sp.A(K). (33); Prof. dr. Titik Nuryastuti, M.Si., Ph.D., Sp.MK(K). (34); Ph.D Tri Wibawa dr. (35)
Tanggal/Date
9 2021
Kata Kunci/Keyword
Abstrak/Abstract
Background: SARS-CoV-2 Delta variant (B.1.617.2) has been responsible for the current increase in COVID-19 infectivity rate worldwide. We compared the impact of the Delta variant and non-Delta variant on the COVID-19 outcomes in patients from Yogyakarta and Central Java provinces, Indonesia.
Methods: In this cross-sectional study, we ascertained 161 patients, 69 with the Delta variant and 92 with the non-Delta variant. The Illumina MiSeq next-generation sequencer was used to perform the whole genome sequences of SARS-CoV-2.
Results: The mean age of patients with Delta and the non-Delta variant was 27.3 ± 20.0 and 43.0 ± 20.9 (p=3x10-6). The patients with Delta variant consisted of 23 males and 46 females, while the patients with the non-Delta variant involved 56 males and 36 females (p=0.001). The Ct value of the Delta variant (18.4 ± 2.9) was significantly lower than the non-Delta variant (19.5 ± 3.8) (p=0.043). There was no significant difference in the hospitalization and mortality of patients with Delta and non-Delta variants (p=0.80 and 0.29, respectively). None of the prognostic factors was associated with the hospitalization, except diabetes with an OR of 3.6 (95% CI=1.02-12.5; p=0.036). Moreover, the patients with the following factors have been associated with higher mortality rate than patients without the factors: age ≥65 years, obesity, diabetes, hypertension, and cardiovascular disease with the OR of 11 (95% CI=3.4-36; p=8x10-5), 27 (95% CI=6.1-118; p=1x10-5), 15.6 (95% CI=5.3-46; p=6x10-7), 12 (95% CI=4-35.3; p=1.2x10-5), and 6.8 (95% CI=2.1-22.1; p=0.003), respectively. Multivariate analysis showed that age ≥65 years, obesity, diabetes, and hypertension were the strong prognostic factors for the mortality of COVID-19 patients with the OR of 3.6 (95% CI=0.58-21.9; p=0.028), 16.6 (95% CI=2.5-107.1; p=0.003), 5.5 (95% CI=1.3-23.7; p=0.021), and 5.8 (95% CI=1.02-32.8; p=0.047), respectively.
Conclusions: We show that the patients infected by the SARS-CoV-2 Delta variant have a lower Ct value than the patients infected by the non-Delta variant, implying that the Delta variant has a higher viral load, which might cause a more transmissible virus among humans. However, the Delta variant does not affect the COVID-19 outcomes in our patients. Our study also confirms the older age and comorbidity increase the mortality rate of COVID-19 patients.
Rumpun Ilmu
Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Form-L1-10th-FrontiersInMedicine_SARSCoV2.pdf
Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
2
fulldoc_is the infection sars cov2 delta variant.pdf
[PAK] Full Dokumen
3
Is the infection of the SARS-CoV-2 Delta variant associated with the outcomes of COVID-19 patients_.pdf
