Inhibition of Orthodontic Relapse by Local Application of Simvastatin-Loaded Gelatin Hydrogel in a Rabbit Model
Penulis/Author
Dr. drg. Niswati Fathmah Rosyida, MDSc (1); Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. (2); Prof. Dr. drg. Pinandi Sri Pudyani, SU.,Sp.Ort(K). (3); Prof. Dr. apt. Akhmad Kharis Nugroho, S.Si., M.Si. (4)
Tanggal/Date
2025
Kata Kunci/Keyword
Abstrak/Abstract
Objectives: This study aims to determine the effect of gelatin–simvastatin hydrogel application on bone remodelling during
relapse.
Materials and Methods: Twenty-four rabbits (Oryctolagus cuniculus) were divided into a control group (n=12) and a treatment group (n=12). The lower incisors were subjected to orthodontic force and moved distally by an open coil spring. The force
(50 cN) was extended for 1week and retained in a new position for 2weeks (stabilisation period). The treatment group received
a local gelatin–simvastatin hydrogel administration during stabilisation, and the control group received only gelatin hydrogel.
The springs were debonded after the stabilisation phase from both groups to facilitate a relapse. The percentage of relapse was
measured in a model study using digital callipers. Levels of OPG and RANKL were analysed using ELISA.
Results: The local application of gelatin–simvastatin hydrogel in the treatment group significantly decreases the relapse percentage and RANKL level. Additionally, the gelatin–simvastatin hydrogel significantly increases the level of OPG and ratio of
OPG/RANKL.
Conclusions: Applying gelatin–simvastatin hydrogel in the retention period can induce bone formation, inhibit orthodontic
relapse and increase tooth stability (in vivo).
Rumpun Ilmu
Ortodonsia
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Inhibition of Orthodontic Relapse by Local Application of Simvastatin Loaded Gealtin Hydrogel in A Rabbit Model.pdf
