Infuence of the SMN antibody on quartz crystal microbalance with dissipation (QCM‑D) surface as an SMN protein biosensor
Penulis/Author
HANIF KHOIRUDIN (1); RIZKY AFLAHA (2); Eldiana Rully Arsetiyani (3); Dr.Sc. Ari Dwi Nugraheni, S.Si., M.Si. (4); dr. Dian Kesumapramudya Nurputra, M.Sc, Ph.D, SpA (5); Prof. Dr. Eng. Kuwat Triyana, M.Si. (6); Dr.Eng. Ahmad Kusumaatmaja, S.Si., M.Sc. (7)
Tanggal/Date
6 2023
Kata Kunci/Keyword
Abstrak/Abstract
The lack of survival motor neuron (SMN) protein levels can lead to spinal muscular atrophy (SMA) disease. In this study, an SMN protein biosensor
based on quartz crystal microbalance with dissipation (QCM-D) was developed. The sensor was coated with polyvinyl alcohol (PVA) nanofber and
doped with SMN antibodies to increase the sensitivity. Scanning electron microscope (SEM) images showed that the nanofber was undamaged
after doping the SMN antibody. The sensitivity of the QCM-D sensor was 21.2 Hz/?ter doping SMN antibodies and had good stability for 3 days.
Moreover, the sensor has been validated using western blot. Thus, the fabricated QCM-D-based biosensor has excellent potential in detecting SMN
levels in human blood plasma.
Rumpun Ilmu
Fisika
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
s43579-023-00492-6.pdf
[PAK] Full Dokumen
2
Infuence of the SMN antibody on quartz crystal microbalance with dissipation (QCM?D) surface as an S-1.pdf
