Influence of Single Nucleotide Polymorphism of ENPP1 and ADIPOQ on Insulin Resistance and Obesity: A Case-Control Study in a Javanese Population
Penulis/Author
RINI ARIANTI (1); NIA LUKITA ARIANI (2); AL AZHAR MUHAMMAD (3); dr. Ahmad Hamim Sadewa, Ph.D. (4); dr. Arta Farmawati, Ph.D. (5); Prof. Dr. Dra. Sunarti, M.Kes. (6); Dr. Dra. Pramudji Hastuti, Apt., M.S. (7); Endre Kristof (8)
Tanggal/Date
11 2021
Kata Kunci/Keyword
Abstrak/Abstract
Abstract: Single nucleotide polymorphisms (SNPs) in obesity?related genes, such as ectonucleotide
pyrophosphatase phosphodiesterase 1 (ENPP1) and adiponectin (ADIPOQ), potentially increase
the risk of insulin resistance, the most common metabolic dysregulation related to obesity. We
investigated the association of ENPP1 SNP K121Q (rs1044498) with insulin resistance and ADIPOQ
SNP + 267G > T (rs1501299) with circulating adiponectin levels in a case–control study involving 55
obese and 55 lean Javanese people residing in Yogyakarta, Indonesia. Allele frequency was determined
by a chi squared test or Fisher’s exact test with an expected value less than 0.05. Odds ratios
and 95% confidence intervals were estimated by regression logistic analysis. The presence of the
Q121 allele of ENPP1 resulted in significantly higher fasting glucose, fasting insulin levels, and
HOMA?IR, as compared to homozygous K121 carriers. The risk of insulin resistance was elevated
in obese individuals carrying Q121 instead of homozygous K121. Adiponectin level was significantly
lower in the obese group as compared to the lean group. Obese individuals carrying homozygous
protective alleles (TT) of ADIPOQ tended to have lower adiponectin levels as compared
to GT and GG carriers, however, we did not find statistically significant effects of the +276G > T
SNP of the ADIPOQ gene on the plasma adiponectin levels or on the development of obesity.
Keywords: ENPP1 gene; ADIPOQ gene; circulating adiponectin; obesity; insulin resistance;
metabolic syndrome; SNP K121Q (rs1044498), SNP + 276G > T (rs1501299)
1. Introduction
Rumpun Ilmu
Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
life-Rini.pdf
[PAK] Full Dokumen
2
Influence of Single Nucleotide Polymorphism of ENPP1 and ADIPOQ on Insulin Resistance and Obesity A Case-Control Study in a Javanese Population.pdf
