Indonesian Herbals Reduce Cholesterol Levels in Diet-Induced Hypercholesterolemia Through Lipase Inhibition
Penulis/Author
Prof. Dr. Ika Puspita Sari, S.Si., M.Si., Apt. (1); Prof. Dr. apt. Arief Nurrochmad, M.Si., M.Sc. (2); apt. Irfan Muris Setiawan, S.Farm., M.Sc. (3)
Tanggal/Date
2013
Kata Kunci/Keyword
Abstrak/Abstract
Water and ethanolic extracts of Guazuma, Gynura, Muraya and Roselle were evaluated for their antihypercholesterolaemia and antilipase activities in high fat diet (HFD)-induced rats. Ethanolic and water extracts were given on days 31–45. Total cholesterol and lipase activity in serum were measured. Guazuma water(Guw) and ethanolic (GuEt) extracts, Gynura water (Gyw) extract, Muraya ethanolic (MEt) extract as well as Roselle water (Rw) and ethanolic (REt) extracts caused reduction in cholesterol levels of HFD-induced rats significantly (17%–23%; p<0.05). The potency of GuEt extract and Rw extract were similar to that of orlistat. Gyw extract, MEt extract and Rw extract reduced dietary fat absorption by inhibiting lipase activity.
