Karya
Judul/Title in vitro test and molecular dosking of Alkaloid compound in marine sponge
Penulis/Author Awik Puji Dyah Nurhayati (1); Prof. Dr. Rarastoeti Pratiwi, M.Sc. (2); Subagus Wahyuono (3); Dr. Drs. Hari Purnomo, M.S., Apt. (4); Syamsudin Abdillah (5)
Tanggal/Date 2015
Kata Kunci/Keyword
Abstrak/Abstract The compound 1,4,9-triazatricyclo[7,3,1,0]trideca-3,5(13),10-trien-8-ol (SA2014) was isolated from the marine sponge Cinachyrella anomala. In vitro assay for SA2014 compound was found to be able to induce cell-cycle arrest at the sub-G1 and G2 /M phases of T47D cancerous cell. A combined dosage between of SA2014 compound and of doxorubicin was able to induce cell-cycle arrest at sub-G1 and G2 /M phases. Molecular docking approach showed that SA2014 compound inhibited cdk2 enzyme. The strength of interaction between SA2014 and cdk2 (docking score = -65,43) was more stable than the interaction between doxorubicin and cdk2 (-36,59). Keywords: C. Anomala,SA2014, cdk2 inhibitor,T47D cell
Rumpun Ilmu Biologi (dan Bioteknologi Umum)
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
12155-9910-1000158.pdf