In Vitro Test and Molecular Docking of Alkaloid Compound in Marine Sponge Cinachyrella anomala against T47D Cell Cycle
Penulis/Author
Awik Puji Dyah Nurhayati (1); Prof. Dr. Rarastoeti Pratiwi, M.Sc. (2); Prof. Dr. apt. Subagus Wahyuono, M.Sc. (3); Prof. Dr. Istriyati, M.S. (4); Dr. Drs. Hari Purnomo, M.S., Apt. (5); Syamsudin Abdillah (6)
Tanggal/Date
2015
Kata Kunci/Keyword
Abstrak/Abstract
The compound 1,4,9-triazatricyclo[7,3,1,0]trideca-3,5(13),10-trien-8-ol (SA2014) was isolated from the marine sponge Cinachyrella anomala. In vitro assay for SA2014 compound was found to be able to induce cell-cycle arrest at the sub-G1 and G2/M phases of T47D cancerous cell. A combined dosage between of SA2014 compound and of doxorubicin was able to induce cell-cycle arrest at sub-G1 and G2/M phases. Molecular docking approach showed that SA2014 compound inhibited cdk2 enzyme. The strength of interaction between SA2014 and cdk2 (docking score = -65,43) was more stable than the interaction between doxorubicin and cdk2 (-36,59).
Keywords : C. anomala; SA2014; cdk2 inhibitor; T47D cell
Rumpun Ilmu
Biologi (dan Bioteknologi Umum)
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
In Vitro Test and Molecular Docking of Alkaloid Compound in Marine Sponge Cinachyrella anomala against T47D Cell Cycle.pdf
[PAK] Full Dokumen
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PC_Rarastoeti_In Vitro Test and Molecular Docking of Alkaloid Compound in Marine Sponge Cinachyrella anomala against T47D Cell Cycle.pdf
