| Judul/Title |
In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane |
| Penulis/Author |
CHOIRUL AMRI (1) ; Prof. Drs. Mudasir, M.Eng., Ph.D. (2); Prof. Drs. Dwi Siswanta, M.Eng., Ph.D. (3); Prof. Drs. Roto, M.Eng, Ph.D. (4) |
| Tanggal/Date |
13 2015 |
| Kata Kunci/Keyword |
|
| Abstrak/Abstract |
Alginate based biopolymer with improved physical and chemical properties after esterification using polyvinyl alcohol (PVA) has been studied for possible application as a hemodialysis membrane. The alginic acid to vinyl alcohol molar ratio was predetermined at 0, 0.1, 0.5 and 1. Mechanical strength, hydrophilicity and Ca2+ adsorption of the membrane before and after modification were evaluated. The obtained PVA-alginate (PVA-Alg) ester membrane was also confirmed using FTIR and SEM. It shows that the PVA-Alg membrane tensile strength is higher than that of native alginate. The water contact angle of the membrane was found to be around 33-50°. The Ca2+ adsorption capacity tends to decrease with the increase in molar ratio. Furthermore, the modified PVA-Alg ester membrane achieves better protein adsorption and platelet adhesion than the unmodified one. It also exhibits a dialysis performance of 47.1-50.0% for clearance of urea and 42.2-44.6% for clearance of creatinine, respectively. It is expected that this PVA-Alg ester may challenge cellulose acetate for potential application as hemodialysis membranes. © 2015 Elsevier B.V. |
| Rumpun Ilmu |
Kimia |
| Bahasa Asli/Original Language |
English |
| Level |
Internasional |
| Status |
|
