| Abstrak/Abstract |
The death on cardiovascular disease can be caused by thrombosis. Thrombosis is triggered by irreversible activity of thrombocyte aggregation. However, almost all prescribed drugs exhibiting antiplatelet activity are associated with a large number of side effects. Then, exploration of medicinal plants which have cardioprotective activity especially as antiplatelet aggregation agent are needed. One of the medicinal plant, Centella asiatica (L.) Urban, has been known to keep people’s health. This study was undertaken to investigate anti-platelet aggregation activity of Centella asiatica ethanolic extract (CEE). There were two groups of CEE, the first group was n-hexane purified CEE (pCEE) while the second group was non-purified CEE (npCEE). In vitro study of antiplatelet aggregation was evaluated by Born method using a Model 490 Chrono Log aggregometer. The blood plasma of male Sprague dawley rats were collected and 10 µM adenosine diphosphat (ADP) was used as agonist. The results showed that both of pCEE and npCEE had anti-platelet aggregation activity on the range concentration of 200, 400, and 800 µg/ml. However, antiplatelet aggregation activity of pCEE and npCEE were not different statistically. Purification process using n-hexane on Centella asiatica herbs powder does not influence its antiplatelet aggregation activity. © 2016, International Journal of Pharmaceutical and Clinical Research. All rights reserved. |
