Karya
Judul/Title In Vitro antioxidant and cytotoxic evaluation of ethyl acetate fraction of Angiopteris ferox Copel tuber against HTB lung cancer cell
Penulis/Author Andi Nur Aisyah (1); Prof. Dr.rer.nat. apt. Raden Rara Endang Lukitaningsih, S.Si., M.Si. (2); apt. Rumiyati, S.Si., M.Si., Ph.D. (3); Marwati (4); Amriani Sapra (5); Nur Khairi (6); Alfat Fadli (7); SYAMSU NUR (8)
Tanggal/Date 2022
Kata Kunci/Keyword
Abstrak/Abstract The tubers of Angiopteris ferox Copel from the Mirrataceae family have been widely used empirically by society for various treatments. This experimentation aimed to discover the antioxidant and anticancer action of the ethyl acetate (EA) fraction of Angiopteris ferox Copel tubers against HTB lung cancer and normal cells in vitro. The EA-fraction obtained from the liquid-liquid extraction was tested for antioxidant activity using the beta carotene degradation and the hydroxyl radical method. The EA-fraction tries the cytotoxic sequel on lung cancer and normal cells using the MTT test method. The outcome achieved that the EA-fraction of the sample has antioxidant activity in reducing lipid peroxidation radicals with an IC50 grade of 30.29 µg /mL (extreme category) and hydroxyl radicals with an IC50 grade of 126.62 µg /mL (medium category). In cytotoxic activity has a medium toxic effect on pulmonary HTB cell line with an IC50 grade of 78.96 µg /mL. In comparison, normal Vero cells have a feeble harmful impact with an IC50 rate >500 µg /mL. It could have culminated that the EA-fraction of Angiopterix ferox Copel has antiradical activity and has a toxic effect on HTB cancer cells but is weak against normal Vero cells. It shall promote as a remedy for the management of lung cancer.
Rumpun Ilmu Farmasi Umum dan Apoteker
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
133-EgyptianJournal-In Vitro Antioxidant.pdf[PAK] Full Dokumen
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