| Abstrak/Abstract |
Objective: The research was conducted by in silico analysis of xanthine oxidase (XO) inhibitors of volatile compounds from ethyl acetate fraction of ethanolic extract of Stelechocarpus burahol (Bl.) Hook F. and Th. leaves. The objective of the research was to determine the active compounds as a potential inhibitor of XO using in silico screening method. Methods: The research was conducted using volatile compounds that were obtained by gas chromatography of ethyl acetate fraction of ethanolic extract of S. burahol leaves and models of XO inhibitor downloaded via Protein Data Bank with code 3BDJ, The five compounds was performed molecular docking against xanthine oxidase enzyme target using Pyrx. Results: Volatile compounds in the ethyl acetate fraction of ethanolic extract were 3 heptene, 2,2,4,6,6-pentamethyl (2.15%), methyl hexadecanoate (4.16%), ethyl tridecanoate (34.63%), methyl octadecanoate (7.26%), and ethyl hexadecanoate (51.8%). The results showed that three of the chemical compounds have lower free energy value as XO inhibitors than oxypurinol. Conclusion: They were ethyl tridecanoate, methyl octadecanoate, and ethyl hexadecanoate with free energy (?G) ?10.7, ?7.6, ?7.1 kcal/mol. |
