Karya
Judul/Title Immunomodulatory Effects of Ethanolic Extract of Thyphonium flagelliforme (Lodd) Blume in Rats Induced by Cyclophosphamide
Penulis/Author Prof. Dr. apt. Arief Nurrochmad, M.Si., M.Sc. (1) ; Dr. apt. Muthi' Ikawati, M.Sc. (2); Prof. Dr. Ika Puspita Sari, S.Si., M.Si., Apt. (3); drh. Retno Murwanti, M.P., Ph.D. (4); Prof. Dr. apt. Agung Endro Nugroho, S.Si., M.Si. (5)
Tanggal/Date 2015
Kata Kunci/Keyword
Abstrak/Abstract The present study aimed to examine the immunomodulatory effect of ethanolic extract of Typhonium flagelliforme (Lodd) Blume in cyclophosphamide-treated rats. The immunomodulatory effects were determined by lymphocytes proliferation, phagocytic activity of macrophages, plasma cytokines of tumor necrosis factor-alpha, interleukin-1alpha, interleukin-10 levels, and killer T cells (CD8+ T cells) counts. The results showed that the administration of ethanolic extract of T flagelliforme reduced immunosupessive effect on lymphocyte proliferation, increase the number and phagocytic activity of macrophages in cyclophosphamide-treated rats. Moreover, the ethanolic extract of T flagelliforme also significantly (P < .05) improved the immune system activities especially the proliferation of CD8+T cells and reduced the suppressive effects on cytokines such as tumor necrosis factor-alpha and interleukin-1alpha. In conclusion, the ethanolic extract of T flagelliforme has immunomodulatory properties in cyclophosphamide-treated rats. The results suggest that T flagelliforme can reduce immunosuppresive effect caused by a chemotherapeutic agent.
Rumpun Ilmu Farmakologi dan Farmasi Klinik
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1Nurrochmad et al 2015.pdf
20_ Nurrochmad et al-2015-ok.pdf[PAK] Full Dokumen
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4a_ JEBCAM 20(3) 2015-cover.pdf[PAK] Halaman Cover
5b_ JEBCAM 2015-Editorial board.pdf[PAK] Halaman Editorial
6c_ JEBCAM 20(3) 2015-table of content.pdf[PAK] Daftar Isi
7f_ JEBCAM Scopus preview.pdf
8Nurrochmad et al 2015-Scopus - Document details | Signed in.pdf
9Immunomodulatory Effects of Ethanolic Extract of Thyphonium flagelliforme (Lodd) Blume in Rats Induced by Cyclophosphamide.pdf[PAK] Cek Similarity