| Abstrak/Abstract |
Introduction : The previous study reported that dietary fiber can improve insulin secretion in health postmenopausal women and overweight individuals. C-peptide is used as a marker of endogenous insulin production and surviving of beta cells.
Aim : To investigate the effect of high-fiber snacks in endogenous insulin secretion in type 2 diabetes patients (T2DM).
Method : Total 20 patients of T2DM, an age of 40-60 years were recruited from the Policlinic of Endocrine, General Hospital Dr. Sardjito, Yogyakarta, Indonesia. The subjects were received daily 32g snacks that made of a mixture Dioscorea esculenta, arrowroot, cassava, and pumpkin, for four weeks. Fasting plasma glucose, insulin, and C-peptide, were measured before and after interventions. Paired t-test was used to evaluate the results.
Results: Intervention of high-fiber snacks for 4 weeks to T2DM patients can increase C-peptide from 0.417 +- 0.004 to 0.512 +- 0.008 (ng/mL), insulin from 9.68 +- 1.42 to 9.78 +- 3.53 (uIu/mL), HOMA-beta from 33.27 +- 1.68 to 4.11 +- 1.75 and reduces significantlly the plasma glucose from 8.90 +-1.33 to 7.91 +- 1.38 (mmol/L)
Conclusion: This study showed that consuming of high-fiber snacks, increased endogenous insulin secretion in T2DM patients. |
