Karya
Judul/Title High Fiber Diet Suppression of TLR4 and NF?? Gene Expression Correlated with TNF-? and IL-6 Levels in Hypertriglyceridemia Rats
Penulis/Author I Gusti Ayu Nyoman Danuyanti (1) ; dr. Arta Farmawati, Ph.D. (2); Prof. Dr. Dra. Sunarti, M.Kes. (3)
Tanggal/Date 19 2018
Kata Kunci/Keyword
Abstrak/Abstract Hypertriglyceridemia causes hypoxia and increases the release of free fatty acids in adipose tissue through lipolysis which stimulates an increase in TLR4 and NF?? levels as well as TNF-? and IL-6 secretion. The high fiber diet had a suppressing effect against TLR4 and NF?? gene expression and decreased TNF-? and IL-6 levels. This study evaluated the effect of high fiber diet (P1= 1.04 g content of fiber/rat/day, P2= 2.07 g content of fiber /rat/day and P3= 3.11 g content of fiber/rat/day) on TNF-? and IL-6 levels as well as expression of TLR4 and NF?? in rats induced by high fat and fructose diet for 6 weeks. The findings indicate that the administration of high fiber diet to the hypertriglyceridemia rats could control body weight gain and significantly reduce TNF-? and IL-6 levels (p<0.05) lower than the hypertriglyceridemia groups when compared before treatment. In addition, the treatment of high fiber diet resulted in suppressing the expression of TLR4 and NF?? gene (p<0.05) when compared with the normal and hypertriglyceridemia groups. The suppression of TLR4 and NF?? were correlated with TNF-? and IL-6 levels. In conclusion, the administration of the high fiber diet to the hypertriglyceridemia rats was able to decrease TNF-? and IL-6 levels possibly by suppression of TLR4 and NF?B gene expression.
Rumpun Ilmu Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
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