Functional Recovery of Axonal Injury Induced by Gelatin-Hydrogel Film and PRP: An Initial Study in Rats
Penulis/Author
Dr. drg. Retno Ardhani, M.Sc. (1); dr. Rina Susilowati, Ph.D. (2); Prof. drg. Ika Dewi Ana, M.Kes., Ph.D. (3)
Tanggal/Date
17 2015
Kata Kunci/Keyword
Abstrak/Abstract
In today’s society, axonal regeneration is considered very important because of high incidence of nerve injuries. The injury may cause vast damage of extracellular matrix leading to the condition wherein cell lost their environment to live. In this situation, new strategies by the introduction of scaffold to function as synthetic extracellular matrix are needed. In the field of tissue engineering, a large variety of carriers and matrices have been utilized as a scaffold to direct axonal growth. In this study, a new strategy by the combined application of gelatin hydrogel film and PRP to induce functional recovery of sciatic nerve crushed injury was investigated in Wistar rat model. Assessment of motorist and sensory functions were done to evaluate the recovery processes. It was found that the application of gelatin hydrogel film with controlled release manner combined with PRP results faster axonal regeneration. Further research by different injury model and other factors investigation are needed to confirm the effectiveness of the strategy.
Rumpun Ilmu
Ilmu Kedokteran Gigi Dasar
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Functional Recovery of Axonal Injury.pdf
[PAK] Full Dokumen
2
Akreditasi Journal of Biomechanical Science and Engineering.pdf
3
12_ SImilaritas Functional recovery of axonal injury induced by gelatin-hydrogel film and PRP An Initial Study in Rats.pdf
