Formulation Nanocapsule of Turmeric Extract, Characterization on Oral Administrationand Its Ability as Antibacterial
Penulis/Author
Prof. Dr. Ir. Zuprizal, DEA., IPU., ASEAN Eng. (2); Prof. Dr. Ir Tri Yuwanta S.U;DEA (3); Dr.rer.nat. Ronny Martien, M.Si. (4)
Tanggal/Date
1 2014
Kata Kunci/Keyword
Abstrak/Abstract
The use of turmeric is restricted by its low solubility in water, therefore it has low bioavailability. This obstacle can be solved by the development of nanoparticle technology. This study aimed to develop nanoparticles formulation using turmeric extract and chitosan as the matrix and sodium tripolyphosphate (STPP) as cross linker, to study its characteristics on oral administration and capabilities as antibacterial. The method used in the formulation of nanoparticles was ionic gelation followed by spray drying on formula A and oven drying at 50ºC on B. The result of nanoparticle or nanocapsule characterizations are: average size of particles on A and B is 428 nm and 840 nm, its zeta-potential on A and B is -11.47 mV and -20.22 mV, with spherical particle morphology. Entrapment efficiency on A and B is 88% and 78%.These formulas also has a good stability in AIF (Artificial Intestinal Fluid) after 3 hours on A and B is 78% and 51%. Its ability as antibacterial agent was evaluated by agar diffusion on E. coli bacterial, both formulas provide a middle inhibition in diameter clear zone 7-10 mm. It was concluded that A formulation of nanocapsule turmeric extract has characteristics can used oral administration and potential as antibacterial
Rumpun Ilmu
Bioteknologi Peternakan
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Formulation Nanocapsule of Turmeric Extract, Characterization on Oral Administration and Its Ability as Antibacterial.pdf
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2
Formulation Nanocapsule of Turmeric Extract Characterization on Oral Administration and Its Ability as Antibacterial.pdf
