| Abstrak/Abstract |
Baldness can result from excessive hair loss, severely affecting the affected person’s mental health. It is preferable to use natural hair growth products instead of synthetic ones owing to the limitations presented by the latter. Cinnamon essential oil (CEO) is known to promote hair growth. Considering its irritative nature and low stability, the CEO’s cinnamaldehyde molecule must be encapsulated in a nanoemulsion system. In this study, we developed an ideal CEO nanoemulsion serum that met all requirements, actively promoted hair growth, and did not irritate the users on the application. We also optimized the formula using a D-optimal design and used the spontaneous nanoemulsification method to generate the nanoemulsion. The characteristics of the cinnamon oil nanoemulsion serum (CEONS) that were assessed included pH, viscosity, organoleptic, droplet size, polydispersity index (PDI), and stability. The Tanaka method was used to study the hair growth activity test in terms of the weight and length of male rabbits’ hair for 28 days. An in vivo cutaneous acute irritation test was performed to evaluate the product's safety. Propylene glycol (34.905%), CEO (12.686%), and cremophor RH 40 (52.408%) constituted the ideal CEONS formula. The final product is a colorless, transparent, and clear oil with a distinct scent. It is slightly viscous, with a pH range of 5.1–5.196. It is non-irritating and stable in storage. For a mean hair length of 2.4 ± 0.308 cm and a hair weight of 1.36 ± 0.16 g, the ideal CEONS droplet size was 44.31 ±0.3024 with a PDI value of 0.25 ± 0.004. This droplet size accelerated hair development. Based on the results, CEO exhibits relatively greater hair growth activity than traditional oils and can be combined to create CEONS. |
