Fe/ZSM-5-Catalyzed-Synthesis of 1,4-Dihydropyridines under Ultrasound Irradiation and Their Antioxidant Activities
Penulis/Author
Yayan Dwi Sutarni (1); Prof. Drs. Bambang Purwono, M.Sc., Ph.D. (2); Prof. Dra. Eko Sri Kunarti, M.Si., Ph.D. (3); Dr. Muhammad Idham Darussalam Mardjan S.Si., M.Sc. (4)
Tanggal/Date
26 2023
Kata Kunci/Keyword
Abstrak/Abstract
A small library of 1,4-dihydropyridines have been synthesized from ethyl acetoacetate, ammonium acetate and
various aldehydes via Hantzsch multicomponent reaction in the presence of Fe/ZSM-5 catalyst under ultrasound
irradiation for 90 min. 1,4-Dihydropyridine derivatives were obtained in 64-86% yields and the heterogeneous
Fe/ZSM-5 catalyst can be employed for four reaction cycles without losing the catalytic activity. All products were
evaluated for their antioxidant activities using the DPPH method and compound 4g was found to be an effective
antioxidant agent with DPPH activity of 83.5%.
