| Abstrak/Abstract |
The inhibitors of class 1 and 2 histone deacetylases (HDACs) have been reported
as novel therapeutic approaches to treat neurodegenerative disorders, depression
and anxiety and the cognitive deficits that accompany many neurodevelopmental
disorders [1]. HDAC inhibitors ameliorated deficit in cognition and stress-related
behaviors in a wide range of neurologic and psychiatric disorders. Preclinically,
behavioral bioassay can be used to predict the influence of compounds for the
treatment of pschyatric illness [2]. Curcumin, PGV-0 and PGV-1 have been
reported to inhibit HDAC2 [3]. However, reports regarding the effect of curcumin
and its analogues on the memory and cognitive function, anxiety and social
interaction behavior are as yet to be examined.
Mice were divided into control and treated groups. They received sodium carboxy
methyl cellulose (as control) and curcumin, PGV-0, PGV-1 orally once a day for
21 days. The behavior tests of social interaction, open field, radial 8-arm maze
and passive avoidance were performed after the induction of brain disorder by
oral administration of 10% ethanol for 7 days (at day 29). To increase the
dissolution and the bioavailability of the test compounds, they were formulated in
Self-Nanoemulsifying Drug Delivery System (SNEDDS).
In different doses, curcumin, PGV-0, and PGV-1 increased social interaction
capability of mice in their groups, reduced depression in open field test, and
increased long term memory and cognitive function in passive avoidance test. |
