| Abstrak/Abstract |
Abstract-
Nowadays coronary artheroslerotic disease
becomes a primary health problem due to its high
morbidity and mortality rate. Such disease is relat
ed to the
poor coronary blood flow quality. Coronary stent
implantation is widely accepted to overcome the pro
blem.
There are various alloys available for stent commer
cially
by different prices. This study was aimed to evalua
te the
various alloys for stent on platelet aggregation ac
tivity. The
materials used under reseach were stainless-steel o
f SS
316L (Otocompo, Sweden) and cobalt-chromium of CoCr
L605 (Remanium Star, Germany). Twenty eights alloys
(14
SS 316L and 14 CoCr L605) were shaped as discs with
10
mm diameter and 2 mm thickness respectively. Venous
blood was drawn from medial cubiti vein from 14 sub
jects
of healthy people with neither established atherosc
lerotic
disease nor risk factors. The drawn blood from each
subject further be divided into three parts: one pa
rt was
left without any induction (control), the other two
parts
were contacted to SS 316L and CoCr L605 respectivel
y.
Platelet aggregation activity in all of the samples
were then
calculated and analyzed by Anova. The result showed
the
average of platelet aggregation activity in percent
age (%)
were 89.96±17.93 (control), 80.16±22.04 (CoCr L605)
, and
80.91±20.68 (SS 316L). The Anova showed p>0.05. In
conclusion, stainless-steel of SS 316L and cobalt-c
hromium
of CoCr L605 did not affect platelet aggregation ac
tivity on
healthy subject; therefore, both of the alloys were
potential
to be used as material choices for stent devices. F
urther
research is needed to evaluate the effect of both a
lloys on
atherosclerotic patients.
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