| Abstrak/Abstract |
The 3,4-Dimethoxychalcone (3,4-DC) is a derivative chalcone compound considered to have potency as a
protection agent against ultraviolet exposure. Ultraviolet A (UV-A) is one of the UV ray components that could
damage the skin and has a more destructive effect than Ultraviolet B (UV-B). The purpose of this research was
to evaluate the activity of 3,4-DC as a protection agent in protecting the skin from UV-A exposure. The
parameters are percent transmission of erythema (%TE) and percent transmission of pigmentation (%TP), UVA Protection Factor (UVA-PF) in vitro, and also to know photostability phenomena due to UV-A exposure.
All determinations in this research were conducted based on UV-Vis spectrophotometry. Determination of %TE
and %TP were conducted using Cumpelik’s method. Determination of UV-A PF in vitro value was done by the
Diffey-Robson method, while UV-A exposure was done with ultraviolet radiation (UVR) simulator. Photostability
of 3,4-DC was observed based on spectra UV before and after UVA exposure.
Results showed that %TE and %TP HPMC gel preparation has the least %TP value (23,64%) which signifies the
best protection, then subsequently microemulgel HPMC (26,00%), gel CMC-Na (31,89%), and microemulgel
CMC-Na (44,12%). In vitro UV-A exposure tests obtained the highest UVA-PF values was HPMC microemulgel
(2,72), then subsequently HPMC gel (2,33), CMC-Na microemulgel (1,17), an |
