| Judul/Title |
Evaluation of anti-fertility effect of aqueous extract of Costus speciosus (Koen.) J.E. Smith rhizome in mice |
| Penulis/Author |
Prof. Dr. Ika Puspita Sari, S.Si., M.Si., Apt. (1) ; Prof. Dr. apt. Arief Nurrochmad, M.Si., M.Sc. (2); SITI RAHAYU (3) |
| Tanggal/Date |
2016 |
| Kata Kunci/Keyword |
|
| Abstrak/Abstract |
Aim: to determine the antifertility effect of the rhizome Costus speciosus (Koen.) J.E.Smith aqueous extract (CSRE) in Balb/C mice. Material and methods: the dried rhizome of Costus speciosus was subjected to extraction by maceration method using water as a solvent. Dose selection for acute oral toxicity was made on the basis of acute oral toxicity study (2000mg/kg) as per OECD guidelines. Anti-fertility dose selection was made on the basis of local community members’ experience of its uses as an anti-fertility substance. The mice were divided into groups in which they were orally administered with the doses of aqueous extract (275, 550, 1100 mg/kg). Results: LD50 CSRE was more than 5000 mg/kg. Oral administration of CSRE for 14 days resulted in a significant reduction in spermatozoa level and quality. Testes histology after CSRE treatments were similar with normal group. Conclusion: The results suggest that CSRE inhibits the spermatozoa quantity and quality on male mice. © 2016, International Journal of Pharmaceutical and Clinical Research. All rights reserved. |
| Rumpun Ilmu |
Farmakologi dan Farmasi Klinik |
| Bahasa Asli/Original Language |
English |
| Level |
Internasional |
| Status |
|
