Ethanolic extract of Pluchea indica Less leaf increases serum growth hormone in lactating rats
Penulis/Author
Dr. dr. Rul Afiyah Syarif, M.Kes. (1); dr. Nungki Anggorowati, Sp.PA(K)., Ph.D. (2); dr. Mia Munawaroh Yuniyanti, M.Biomed. (3); Prof. Dr. Mae Sri Hartati Wahyuningsih, Apt., M.Si. (4)
Tanggal/Date
31 2021
Kata Kunci/Keyword
Abstrak/Abstract
The objectives of the study were to evaluate the effect of ethanolic extract of P. indica Less leaf (EPI) on serum growth hormone (GH), milk yield, body weight gain of dams, and dam’s organ weight in lactating rats. A total of 25 lactating rats with six pups were randomized and distributed to one of five treatments (control (RO water), standard (domperidone 2,5 mg/kg BW/day), EPI 250 (250 mg/kg BW of EPI), EPI 500 (500 mg/kg BW of EPI), and EPI 750 (750 mg/kg BW of EPI)). The treatment was administered daily starting from the 2nd until 15th of lactation day. On the 16th day serum growth hormone level, body and organ weight of rats were measured. Serum GH levels in the EPI 750 group (1963.25 ± 360.91 pg/µL) increased significantly compared to the domperidone (409.46 ± 28.80 pg/µL) and the control group (723.40 ± 95.78 pg/µL, p<0>0.05). There was significant body weight gain in the EPI 750 group compared with the domperidone group. There was no significant difference in organ weight gain in each group. The study revealed that ethanolic extract of P. indica Less leaf can increase serum growth hormone in lactating rat.
Rumpun Ilmu
Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language
English
Level
Nasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
2021 Rul et al MOT Ethanolic extract P indica Growth Hormoe lactating Rtas.pdf
[PAK] Full Dokumen
2
SIMILARITY_Ethanolic extract of Pluchea indica Less leaf increases serum growth hormone in lactating rats.pdf
