Objectives: This study aims to understand the epidemiological features and level of genetic similarity
in the SARS-CoV-2 from different geographical areas in The Southeast Asia Region during an early
pandemic.
Methods: The data on COVID-19 cases in Southeast Asia was collected from
https://worldometer.info/ and extracted independently. Complete genome SARS-CoV-2 nucleotide
sequence data was obtained from GISAID and NCBI online platforms. The sequences were aligned
using MEGA X software and identified RdRp and Spike genes using UGENE software. The phylogenetic
was constructed using MEGA X software to know the similarity of these genes among isolates in the
Southeast Asia region.
Results: The result showed that the first case in Southeast Asia was reported in January 2020. The
highest number of COVID-19 cases and death were reported from populous and suffering countries.
The phylogenetic results showed an identical solid (100%) among isolates, except for the Philippines-5
isolate. The Wuhan-Hu-1 (China) SARS-CoV-2 isolate (Acc. NC_045512) was transmitted to other
countries in Southeast Asia region with various mutations in the spike protein.
Conclusion: During the early pandemic, all countries in the Southeast Asia region reported COVID-19
cases. Indonesia became the country with the highest number of COVID-19 cases and deaths. The
level of similarity of the RdRp gene in the SARS-CoV-2 in Southeast Asia is higher than the Spike
genes. J Microbiol Infect Dis 2022; 12(4):139-148.
Keywords: Epidemiology, Phylogeny, SARS-Cov-2, Pandemic
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Epidemiological Features and Phylogeny of SARS-CoV-2 Circulating in the Southeast Asia in Early Pandemic.pdf
