Enhanced magnetic hyperthermia properties of reduced graphene oxide-modified cobalt ferrite nanoparticles synthesized using green approach
Penulis/Author
Dyah Ayu Larasati (1); DESKA LISMAWENNING P (2); MAHARDIKA YOGA DARMAWAN (3); NURUL IMANI I (4); Nugraheni Puspita R (5); Nining Sumawati Asri (6); Julia Angel (7); Dr. Juliasih Partini, S.Si., M.Si. (8); Prof. Dr.Eng. Edi Suharyadi, S.Si., M.Eng. (9)
Tanggal/Date
2025
Kata Kunci/Keyword
Abstrak/Abstract
Localized cancer therapy that can effectively target and kill cancer cells is a significant issue in the field of biomedicine. The modification of magnetic and fluorescent nanoparticles as heat mediators for magnetic hyperthermia is a novel and efficient strategy. This study investigated the potential of novel reduced graphene oxide-modified cobalt ferrite (CoFe2O4/rGO) nanoparticles (NPs) as a magnetic hyperthermia agent. NPs successfully fabricated using a green synthesis approach utilizing plant leaf extracts. X-ray diffraction spectra indicate the presence of cubic spinel phase CoFe2O4 and rGO phases NPs. The crystal size tends to decrease with increasing rGO concentration, ranging from 9.9 to 9.0 nm. Morphological images showed that the particles are nearly spherical and are well-attached to the rGO sheets, with the particle size decreasing from 14.8 to 13.3 nm after modification. Magnetic property analysis indicated that the NPs exhibit ferromagnetic behavior. Subsequently, for magnetic hyperthermia investigation, the NPs were dispersed in three different media—deionized water, ethylene glycol, and DMSO—to evaluate their heating characteristics based on specific absorption rate (SAR) in alternating magnetic fields at varying rGO concentrations. The SAR of CoFe2O4 was 178 and significantly increased to 736 mW/g for CoFe2O4/rGO. The findings suggest that green-synthesized CoFe2O4/rGO NPs are promising candidates for magnetic hyperthermia applications in cancer therapy. Their high saturation magnetization and favorable SAR values position them as effective candidates for magnetic hyperthermia, especially for cancer therapy and other biomedical applications.
