ACADSTAFF UGM
| Judul/Title | Eliminate Dengue Project (EDP): Introducing Wolbachia technology as a supplementary alternative strategy to control dengue |
| Penulis/Author | dr. Riris Andono Ahmad, MPH, Ph.D (1) ; dr. Citra Indriani, MPH. (2); Warsito Tantowijoyo (3); Prof. dr. Eggi Arguni, M.Sc., Ph.D., Sp.A(K). (4); Bekti Andari (5); Prof. dr. Adi Utarini, M.Sc., MPH.,Ph.D. (6) |
| Tanggal/Date | 28 2018 |
| Kata Kunci/Keyword | |
| Abstrak/Abstract | Introduction: Wolbachia is a proven technology to prevent virus replication which leads to reduction of dengue transmission. WHO has considered Wolbachia as a potential vector control technology and recommended carefully planned pilot deployment under operational conditions accompanied by rigorous independent monitoring and evaluation that builds entomological capacity to support operational use. This presentation explores the implementation challenges faced by EDP to introduce this technology and strategies to ensure community acceptance for Wolbachia deployment. Methods: EDP is a multi-phases research studies which consist of 4 phases: Phase 1. Assessing safety and feasibility of the technology; Phase 2. Small scale release to assess the feasibility of Wolbachia infected mosquitos to establish in natural environment; Phase 3. Assessing the impact of Wolbachia deployment through RCT (AWED Study); Phase 4. Adoption and scale up. Result: Result from Phase 1 showed that: 1) Wolbachia is commonly found among insects in the study area and genetically identical with Wolbachia used in the study; 2) Wolbachia infected mosquito used in the study has strong vector competence capacity, and has similar genetical and behavior characteristics with local mosquitos. Phase 2 results: 1) Wolbachia was successfully established in the mosquito natural environment; 2) Wolbachia infected mosquito in the field retained similar vector competence capacity; 3) No dengue local transmission found in the area with Wolbachia establishment. Phase 3 a Cluster Randomized Controlled Trial (CRCT) study is still an ongoing study (The Awed Study). Twenty fours clusters were randomized, with 12 clusters were selected as intervention areas. We assume that there will be a 50?crease of dengue cases in intervention areas. Conclusion: Wolbachia is a potential technology for dengue control strategy. Initial results show Wolbachia capacity to prevent dengue transmission. The AWED Study to assess the impact of wide scale Wolbachia release on dengue transmission is still on progress. |
| Level | Internasional |
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