Karya
Judul/Title Effects of While-Skinned Sweet Potato (Ipomea batatas, L) on Pancreatic Beta Cells and Insulin Expression in Streptozotocin Induced Diabetic Rats
Penulis/Author AAN ROYHAN, DR. (1) ; dr. Rina Susilowati, Ph.D. (2); Prof. Dr. Dra. Sunarti, M.Kes. (3)
Tanggal/Date 2009
Kata Kunci/Keyword
Abstrak/Abstract White-skinned sweet potato has been used as a folk medicine for the treatment of diabetes and other diseases. The aim of this study was to investigate the mechanism of white-skinned sweet potato (Ipomoea batatas L.) on reducing blood glucose level in streptozotocin induced diabetic rats as a preliminary study. Twenty two male Rattus norvegicus rats were divided into 6 groups (4 treatment groups and 2 control groups). Streptozotocin was injected intraperitoneally at a single dose of 60 mg/kg BW for induction of diabetes in treatment groups and diabetic control group. White-skinned sweet potato’s flour suspension (100, 200, 400 and 800 mg/kg BW/day) were administered orally to treatment groups for 4 weeks. Blood samples were collected from retro-orbital puncture before treatment, 2 weeks and 4 weeks after treatment and were analyzed for blood glucose by GOD-PAP method. At day 29 after treatment rats were killed by decapitation and pancreas were removed for immunohistochemical staining using anti-insulin antibody. White-skinned sweet potato had a significant blood glucose lowering effect and increased the number of pancreatic beta cells and insulin expression in a dose dependant manner in diabetic condition. These results suggest that white-skinned sweet potato produced hypoglycemic activity by inducing pancreatic beta cells regeneration and increasing insulin expression.
Rumpun Ilmu Ilmu Kedokteran Dasar & Biomedis
Bahasa Asli/Original Language English
Level Nasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
1Effects of White-Skinned Sweet Potato (Ipomoea batatas L_) on Pancreatic Beta.pdf