Effects of 15 mg meloxicam administered before odontectomy on pain, facial edema, trismus, and expressions of TNF-alpha following odontectomy of impacted mandibular third molar
Penulis/Author
MELISA RUTH (1); drg. Cahya Yustisia Hasan, Sp.BM. (2); drg. Rahardjo, S.U., Sp.BM. (3); Dr. dr. Rustamaji, M.Kes. (4)
Tanggal/Date
2020
Kata Kunci/Keyword
Abstrak/Abstract
Objective:To evaluate the effects of 15 mg meloxicam administered
60 minutes before odontectomy on pain, facial edema, trismus and
expressions of TNF-? after odontectomy of impacted mandibular third
molar.
Material and Methods: A total of 24 patients were randomized into
treatment groups, each with 12 patients: Group A was administered
with 15 mg of meloxicam; and Group B with placebo. Drugs were
administered orally 60 minutes prior to surgery. Observation of pain
(seen from VAS scores), facial edema (seen from swollen cheeks),
trismus (seen from mouth opening) and expressions of TNF-? (measured
from saliva by ELISA method), performed before odontectomy, H+1
(24 hours after odontectomy) and H+3 (72 hours after odontectomy).
Results: Patients who received 15 mg meloxicam 60 minutes before
odontectomy showed less postoperative pain (p=0.000), less facial
edema (p=0.000) and lower expressions of TNF-? (p=0.000). No
differences were found in mouth opening between the meloxicam
group and placebo group (p=0.522). The higher level of TNF-? level
will lead to higher level of pain, greater facial edema and causes
smaller mouth opening.
Conclusion: Oral administration of 15 mg meloxicam 60 minutes
prior to odontectomy was found more effective in reducing pain,
facial edema and expressions of TNF-? after odontectomy of impacted
mandibular third molar compared with placebo.
