| Abstrak/Abstract |
Tooth extraction is procedure of removing a tooth from the socket. Kirinyuh leaves (Chromolaena odorata) contain flavonoids, saponins, and tannins that can help in the woundhealing process after tooth extraction. This study aimed to determine the effect of applying kirinyuh leaf ethanol extract on the density of collagen fibers in the wound after tooth extraction in guinea pigs. Sixty male guinea pigs (Cavia cobaya) were divided into five groups: negative control, positive control, and treatment groups with kirinyuh leaf ethanol extract concentrations of 2.5%, 5%, and 10%. Extracts of kirinyuh leaf were made as topical products. Subjects’ teeth were extracted on the same day, and extract of kirinyuh leaves was applied topically on the wound. Subjects were euthanized, and histopathological specimens were obtained on days 3, 7, 10, and 14 after tooth extraction, subjected to Mallory trichrome staining, and then observed under a microscope. The treatment groups had higher density of collagen fibers than the controls. Statistical analysis showed significant differences in all groups and days. In conclusion, the ethanol extract of kirinyuh leaves can increase the density of collagen fibers in post-tooth extraction wounds, and 10% kirinyuh leaf extract has the highest rate of increasing collagen fiber density. |
