Effective Empiric Antimicrobial Therapy of Bacterial Meningitis and Encephalitis
Penulis/Author
DIYAN AJENG R (1); Prof. Dr. Ika Puspita Sari, S.Si., M.Si., Apt. (2); Prof. Dr. Tri Murti Andayani, Sp.FRS., Apt. (3); Prof. dr. Titik Nuryastuti, M.Si., Ph.D., Sp.MK(K). (4)
Tanggal/Date
31 2021
Kata Kunci/Keyword
Abstrak/Abstract
Bacterial meningitis-encephalitis (ME) management therapy is critical to appropriately
manage clinical outcomes. This study aims to provide recommendations on appropriate
empiric antimicrobial to support the healing period and reduce the risk of disease
severity. A cross-sectional study, including inpatients without comorbid diagnosed with
bacterial ME, was conducted, and records of antimicrobial prescriptions were obtained.
Sociodemographic, clinical (diagnostic), and pharmacological (antimicrobial) variables
were assessed. Through multivariate analysis, variables associated with the use of
antimicrobials for bacterial infections were identified. A total of 45 patients with ME.
The patients, who were from surrounding Center Java and Yogyakarta, had a mean age
of 11.27 ± 16.93 years and a male predominance of 56.9% (n = 23). The most frequent
bacterial infections were caused by: S. haemolyticus and S. epidermidis (25.93%). A total
of 100% the patients (n = 45) received a prescription for empiric antibiotics,
predominantly 3rd generation cephalosporin e.c ceftriaxone (35.56%) and cefotaxime
(13.33%). Empiric antimicrobials are frequently prescribed for the first management of
bacterial ME, are considered an inappropriate practice due to a lack of clinical benefits,
increased generation of antimicrobial resistance, and risk of adverse reactions due to
the use of medications that patients do not require. Drug utilization studies are a great
tool for monitoring how antimicrobial is being used and planning interventions to
improve their use.
Rumpun Ilmu
Farmakologi dan Farmasi Klinik
Bahasa Asli/Original Language
English
Level
Nasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Pharmacy Diyan Ajeng.pdf
[PAK] Full Dokumen
2
EC Diyan .pdf
Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)
3
Effective Empiric Antimicrobial Therapy.pdf
[PAK] Full Dokumen
4
Akreditasi Jurnal Farmasi Indonesia UMP.pdf
Dokumen Pendukung Karya Ilmiah (Hibah, Publikasi, Penelitian, Pengabdian)