| Abstrak/Abstract |
Odontectomy is the surgical removal of teeth by making a mucoperiosteal flap and reducing the jawbone. This
procedure is likely to cause injury and damage to soft and hard tissues, stimulate inflammatory responses, and
generate release of proinflammatory cytokines, one of which is TNF- ɑ, resulting in the facial swelling, intraoral
redness, and pain. This study was aimed at observing effects of 40 mg methylprednisolone, administered 1 hour before
odontectomy on facial swelling, intraoral redness, and pain and level of TNF-ɑ after odontectomy. The randomized
placebo-control trial study involved 24 subjects who underwent odontectomy at the Oral Surgery and Maxillofacial
clinic of Prof. Soedomo Dental Hospital, Universitas Gadjah Mada. To comply with the inclusion criteria, the subjects
were divided into placebo group (12 patients) and methylprednisolone group (12 patients). The observation of facial
swelling, intraoral redness, pain (VAS) and level of TNF-ɑ (ELISA) was done before odontectormy, H+1 (24 hours after
odontectomy) and H+3 (72 hours after odontectomy). The data gathered were analyzed using Repeated Measures
ANOVA and post-hoc Bonferroni (p < 0.05). The results showed that those administered with methylprednisolone an
hour before odontectomy experienced less postoperative facial swelling (p = 0.000), a lower score of intraoral redness
(p = 0.000), a lower score of pain (p = 0.000) and a lower level of TNF-ɑ (p = 0.000) compared to the placebo. The
changes in TNF-α showed the strongest correlation with the changes in postoperative pain and intraoral redness
compared with facial swelling. Oral administration of 40 mg methylprednisolone an hour before odontectomy is more
effective in reducing facial swelling, intraoral redness, pain and level of TNF-ɑ following odontectomy of mandibular
third molar compared with the placebo. |
