| Penulis/Author |
Atika Wahyu Puspitasari (1); Prof. Dr. Susi Ari Kristina, S.Farm., M.Kes., Apt. (2) ; Prof. Dr. Satibi, S.Si., M.Si. Apt. (3); Prof. Dra. Raden Ajeng Yayi Suryo Prabandari, M.Si., Ph.D. (4) |
| Abstrak/Abstract |
Oral chemotherapy poses challenges regarding patient medication
adherence. Pharmacists play a vital role in supporting medication adherence
to achieve the effectiveness of therapy. This review aimed to evaluate the
impact of pharmacist interventions on medication adherence in patients with
cancer taking capecitabine. The literature was systematically reviewed using
Scopus, ScienceDirect, Sage Journal, Springer Link, PubMed, and Google
Scholar. Key text words included “adherence, pharmacist intervention,
capecitabine, oral chemotherapy, and cancer.” We collected original articles
published from January 2010 to June 2021 in English that reported
pharmacist interventions to enhance capecitabine adherence in adult patients
with cancer and assessed adherence rates pre- and post-intervention. Two
independent researchers extracted data relevant to inclusion criteria and
determined the methodological quality of studies using the Joanna Briggs
Institute Critical Appraisal Checklist Tools. A total of 4179 articles were
retrieved, of which five were eligible for review. The most common
pharmacist intervention strategy was a combination of patient education,
with oral and written information provided. Components of patient education
were the characteristics of capecitabine, including its mechanism of action,
side effects, and their management; current therapeutic regimen; importance
of adherence; and risk of non-adherence. Pharmacist interventions provide
beneficial impacts on medication adherence, beliefs about medication, and
tolerability of side effects. The findings suggest that pharmacist interventions
support medication adherence improvement and highlight the role of
pharmacist interventions in pharmaceutical oncology care services. Further
studies are necessary to assess pharmacist interventions’ long-term effects
and clinical outcomes. |
