Effect of Contraception on the Expression of Cytokeratin 1 in Epithelial Cells of the Palatal Mucosa and Salivary Estrogen
Penulis/Author
Prof. Dr. drg. Juni Handajani, M.Kes., Ph.D (1); Urfa Tabtila (2); Swastiana Eka Yunita (3)
Tanggal/Date
4 2021
Kata Kunci/Keyword
Abstrak/Abstract
Sex hormones may affect keratinization of the epithelial cells. Cytokeratin 1 (CK1) is expressed in keratinized cells of oral mucosa. The aim is to analyze the effect of contraception on the CK1 expression of epithelial cells in the palatal mucosa and salivary estrogen. Forty females were divided equally into pill, injection, intrauterine device, and non-contraception (control) groups. Saliva samples were collected by unstimulated method. Salivary estrogen was measured by using an ELISA kit. Epithelial cells of the palatal mucosa were swabbed using cytobrush then treated by immunohistochemistry staining. The primary antibody of CK1 was used to analyze the expression of the protein. The results of ANOVA revealed the significant effect of contraception on salivary estrogen and CK1 [removed]p < 0> 0.05) was found. Pearson correlation analysis indicated a strong correlation between salivary estrogen and CK1 [removed]r = 0.880). Hormonal contraception could increase the keratinization of epithelial cells by increasing CK1 expression and correlate with increasing salivary estrogen.
