Effect of Concentration of Snail Mucus Gel (Achatina Fulica) on Collagen Density and Wound Closure Rate in Wistar Rat Skin Punch Biopsy Wounds
Penulis/Author
ANTONIUS SURYA S P (1); drg. Rahardjo, S.U., Sp.BM. (2); drg. Cahya Yustisia Hasan, Sp.BM. (3); Dr. drh. Tri Wahyu Pangestiningsih, M.P. (4)
Tanggal/Date
21 2021
Kata Kunci/Keyword
Abstrak/Abstract
Collagen production and deposition is crucial to replace damaged tissue. Glycosaminoglycans in snail mucus has high biological value for wound healing. This study aims to determine the effect of concentration differences of snail mucus gel on collagen density and wound closure rate in skin punch biopsy wounds. Quasi experimental research was done using 6 Wistar rats, each wounded with 4 punch biopsy wound in dorsa skin, and subsequently applied with 24%, 48%, 96% snail mucus gel and 3% CMC-Na gel. Collagen density was measured on 2nd and 7th day using histophotometry analysis. Wound closure rate was measured from wound area on the 4th and 7th day.
Data analysis using 2-way Anova showed significant differences in collagen density (p=0.000) and wound closure rate (p=0.000) of all treatment groups and observation period, but there is no interaction between them. Post hoc LSD showed significant difference in wound closure rate between control groups and all treatment groups (p=0.000), but there is no significant difference between treatment groups (p>0.05). Significant differences of collagen density was found between controlgroups and all treatment groups (p>0.05). Significant difference of collagen density between treatment groups only found on snail mucus gel 96% (p<0.05).
In conclusion, topical application of snail mucus gel can increase collagen density and wound closure rate in wistar rat skin punch biopsy wound healing. Wound closure rate was not influenced by concentration differences of snail mucus gel, although the collagen density proved to be much higher in the 96% snail mucus gel group.
Experimental article (J Int Dent Med Res 2021; 14(2): 574-579)
Rumpun Ilmu
Ilmu Kedokteran Gigi
Bahasa Asli/Original Language
English
Level
Internasional
Status
Dokumen Karya
No
Judul
Tipe Dokumen
Aksi
1
Cover - Journal of International Dental and Medical Research.pdf
[PAK] Halaman Cover
2
Table of Contents - Journal of International Dental and Medical Research.pdf
[PAK] Daftar Isi
3
Editorial Board - Journal of International Dental and Medical Research.pdf
[PAK] Halaman Editorial
4
Collagen - Full Dokumen - Journal of International Dental and Medical Research.pdf
[PAK] Full Dokumen
5
Effect of Concentration Differences of Snail Mucus Gel (Achatina Fulica).pdf
[PAK] Cek Similarity
6
Similaritas-Effect of Concentration Differences of Snail Mucus Gel (Achatina Fulica).pdf
[PAK] Cek Similarity
7
Effect of Concentration Differences of Snail Mucus Gel.pdf
