Karya
Judul/Title Effect of Chemotherapy on Gingival Crevicular Alkaline Phosphatase Level in Patients with Breast Cancer
Penulis/Author drg. Nur Rahman Ahmad Seno Aji, MDSc., Sp.Perio (K) MP (1) ; Prof. Dr. drg. Ahmad Syaify, Sp.Perio(K) (2); drg. Kwartarini Murdiastuti, Sp.Perio(K)., Ph.D. (3); Dr. dr. Kartika Widayati, SpPD-KHOM (4)
Tanggal/Date 2020
Kata Kunci/Keyword
Abstrak/Abstract Introduction: Chemotherapy is one of the modalities for treating breast cancer. Chemotherapy is conducted by administering cytostatic drugs to intervene in the genetic and cellular division of cancer cells. In vitro studies show that exposing osteoblasts to chemotherapeutic agents results in impaired function and activity as indicated by decreased alkaline phosphatase (ALP) activity. Gingival crevicular fluid (GCF) is considered a biomarker of the oral cavity and can be used to detect cellular events in periodontal pockets. The aim of this study was to determine the effect of chemotherapy on ALP activity in gingival crevicular fluid. Methods: Patients diagnosed with breast cancer at the “Tulip” Integrated Cancer Installation of Dr. Sardjito General Hospital who were scheduled to undergo chemotherapy were recruited as research subjects. Gingival crevicular fluid was taken from the maxillary anterior teeth before the subjects underwent chemotherapy and 7 days after chemotherapy. The ALP assay of gingival crevicular fluid was conducted with an ALP Kit (DiaSys) and absorbance was determined using a UV-Vis spectrophotometer at a wavelength of 405 nm. Data were analyzed by the paired t-test. Results: The results showed significant differences (p < 0.05) before and after chemotherapy. Conclusion: Chemotherapy could affect gingival crevicular ALP activity in patients with breast cancer at the “Tulip” Integrated Cancer Installation of Dr. Sardjito General Hospital.
Rumpun Ilmu Periodonsia
Bahasa Asli/Original Language English
Level Internasional
Status
Dokumen Karya
No Judul Tipe Dokumen Aksi
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