The effect of regular exercise and estrogen replacement therapy on the duration of heart’s muscle repolaritation after bilateral ovariectomized sprague dawley mice
Penulis/Author
Prof. Dr. dr. Denny Agustiningsih, M.Kes., AIFM. (1)
Tanggal/Date
2010
Kata Kunci/Keyword
Abstrak/Abstract
After the menopausal stage, the nature of electricity in women's heart will change. As the decrease of estrogen, the rate of arrythmia and the mortality caused by arrythmia increases. Prolonged time repolarization of the cardiac's muscle is assumed to be the caused of arrythmia in menopausal women. The prolonged time of repolarization can be observed from ECG. The ECG shows leghtening of QTc interval. The aim of this research is to compare the effect of regular medium dose of exercise on the shortening of cardiac's muscle repolarization, on bilateral ovariectomized mice and estrogen replacement therapy mice. The subjects of this study are 24 Spraque Dawley mice, aged 40-50 days. From the study we conclude that regular swimming for 1 hour, 5 times a week for 10 weeks can cause the shortening of cardiac's muscle repolarization in bilateral ovariectomized mice. The estrogen replacement therapy to the mice after bilateral ovariectomy can prevent the prolonged repolarization of cardiac's muscle. The combination of swimming and estrogen replacement therapy can also prevent the prolonged repolaritation of mice's cardiac's muscle after bilateral ovariectomy
