| Abstrak/Abstract |
Solubility significantly impacts the biopharmaceutical process of drugs, dictating dissolution rates and oral bioavailability. Low solubility necessitates higher drug loads to compensate. Solid dispersion offers a solution for enhancing solubility, where polymers play a crucial role. This review investigates the influence of polymer type and quantity on solid dispersions, drawing from 45 diverse references across various journal databases namely Scopus, ScienceDirect, and Google Scholar. Amorphous solid dispersion (ASD) emerges as a contemporary method for boosting drug solubility by dispersing it in a carrier, typically a hydrophilic polymer. This approach alters the thermodynamic equilibrium of the drug in solution, enhancing solubility and dissolution rates. Its amorphous structure, characterized by a random molecular arrangement, increases thermodynamic activity, resulting in higher solubility and dissolution rates. Polymers, the primary component alongside the active substance in ASD, dictate its success. Polymer selection, along with additives and their proportions, is crucial. Surfactants are often incorporated into a ternary system to synergistically enhance dissolution rates, maintaining drug supersaturation via mechanisms like reducing molecular mobility and providing a plasticizing effect. |
