| Penulis/Author |
apt. Navista Sri Octa Ujiantari, S.Farm., M.Sc., Ph.D. (1); Andy Eko Wibowo, S.Farm., M.Sc., Apt. (2) ; Prof. Dr. apt. Ratna Asmah Susidarti, MS. (3) |
| Abstrak/Abstract |
The high amount of free radicals in the body could stimulate oxidative stress which has been implicated in several diseases such as cancer, inflammation, aging, and cardiovascular diseases. The presence of antioxidants can diminish the reactivity of free radicals. However, the antioxidant defense system in the body may be insufficient thus intake of dietary antioxidants is recommended. Natural flavonoid such as chalcone has been known to exert several biological activities, especially antioxidant activity. Previous study proved that replacement of benzene ring into pyridine ring could improve the antioxidant activities. A pyridine-based chalcone, compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone (AEW-1) was successfully synthesized using microwave radiation and several studies reported its biological activities such as antiinflammation, anticancer, and antibacterial activities. Those activities are thought to be related to antioxidant mechanisms. Therefore, this study aimed to evaluate its antioxidant activity. Methods: The antioxidant activities were performed with three different methods: DPPH scavenging activity, ferric reducing power, and metal chelating capacity. Results: AEW-1 showed DPPH scavenging activity, ferric reducing power, and metal chelating capacity with IC50S values of 4,471 ± 0,052 μg/mL; 156.56 ± 4.42μg/mL; and 6,273 ± 0,025 μg/mL, respectively. Conclusions: Our results found that AEW-1 had quite potent antioxidant activity. |
