| Abstrak/Abstract |
Introduction: Photoacoustic imaging (PAI) uses nonionizing radiation for tumor features and
thus can be used as an alternative method for medical features without inducing biological
effects. The study aimed to characterize a PAI system utilizing a 650-nm diode laser to detect
pathological conditions (benign and malignant tumors) in human uterine tissue, including
healthy tissue. The benign tumor tissue used is a leiomyoma, which is a benign tumor that
occurs in the middle layer of the uterine (myometrium). Meanwhile, the malignant tumor tissue
used is a type of endometrial carcinoma, which is a malignant tumor that occurs in the inner
layer of the uterine (endometrium).
Methods: The human uterine tissue was obtained from the hysterectomy procedure conducted
to determine the histopathological diagnosis. The PAI system uses a condenser microphone as
the acoustic signal detector and a diode laser as the radiation source.
Results: The characterization results of the PAI based on a diode laser with a wavelength of 650
nm and power of 250 mW showed an optimal performance for human uterine tissue in a laser
modulation frequency of 16 500 Hz and a duty cycle of 50%. Obtained photoacoustic images
could differentiate between healthy uterine, leiomyoma, and endometrial carcinoma tissues,
as indicated by the intensity level values in each tissue type. Healthy uterine, leiomyoma, and
endometrial carcinoma tissues had intensity values of 11.87, 26.84, and 37.26 a.u, respectively.
A One-way ANOVA test with Bonferroni post hoc analysis revealed a significant difference in
the acoustic intensity level between the groups (P < 0.05).
Conclusion: The resulting intensity levels indicate a direct correlation with the nature of uterine
tumors. The poorer the differentiation, the higher the resulting intensity. |
