| Penulis/Author |
dr. Dian Kesumapramudya Nurputra, M.Sc, Ph.D, SpA (1) ; dr. Amalia Setyati, Sp.A(K). (2); dr. Nur Arfian, Ph.D. (3); dr. Endy Paryanto, MPH., Sp.A(K). (4); Zulvikar Syambani Ulhaq (5) |
| Abstrak/Abstract |
Acute respiratory tract infection (ARTI) rank among the top ten most common illnesses affecting children in Indonesia. Myxovirus resistance-A (MxA) protein, selectively induced by the activation of type I interferon in response to viral infections, has emerged as a promising biomarker to diagnose viral ARTI. Notably, the activation of interferons is thought to be inflenced by plasma vitamin A and zinc levels. Therefore, our study aims to investigate the level of MxA
expression in children with vitamin A and zinc defiiencies when experiencing viral ARTI. This cross-sectional study involved a total of 113 subjects, including 53 diagnosed with ARTI due to viral causes based on validated clinical scoring criteria, and 50 healthy controls. To determine the etiology, we conducted blood cultures and employed RT-PCR analysis on nasopharyngeal swabs. Additionally, we assessed plasma levels of vitamin A, zinc, and MxA protein expression. Our fidings revealed that subjects with ARTI displayed elevated MxA expression compared to controls. Specifially, MxA expression levels in ARTI cases of viral origin were signifiantly higher than those in both control and bacterial origin. On closer examination, the vitamin A and zinc non-defiient group exhibited higher MxA expression levels in comparison to the defiient group. However, it is notable that the expression levels in the defiient group remained higher than those in the control group. In summary, MxA protein expression was found to be lower in children with vitamin A and zinc defiiencies when compared to those without defiiencies in cases of viral ARTI. Thus, MxA expression may serve as a diagnostic tool for distinguishing viral from bacterial ARTI, especially in populations where the prevalence of micronutrient-defiient children is high, such as in Indonesia.
This output contributes to the following Sustainable Development Goals (SDGs); SDG 2: Zero Hunger |
