| Abstrak/Abstract |
Self-nano emulsifying drug delivery system of ethyl acetate fraction from mangosteen peel (EAF-MP) was developed under quality by design approach for improvement of diffusion and precut absorption. Preliminary screening was performed to select proper components combination. Simplex Lattice Design was employed as the statistical tool to optimize the formulation variables. X1 (Tween 80), X2 (PEG 400) and X3 (Virgin Coconut Oil). The system was assessed for transmittance, emulsification time, PH, and drug loading. Following optimization, the value of formulation components (X1, X2, and X3) were 4, 61%. 1% and 1, 38% respectively (150 mg of EAF-MP). The optimized formulation of EAF-MP had a mean nanoemulsion droplet diameters of 11, 6 nm. The stability of the optimized formulation was retained after storage at 25 C for three months. |
