| Abstrak/Abstract |
Collagen(Col) isa naturallyavailablematerial andiswidely usedin thetissueengineering and medical ?eld owing to its high biocompatibility and malleability. Promising results on the use of Col were observed in the periodontal application and many attempts have been carried out to inculcate Col for gingival recession (GR). Col is found to be an excellent provisional biosca?old for the current treatment in GR. Therefore, the aim of this paper is to scrutinize an overview of the reportedCole?ectfocusingonin vitro,in vivo,andclinicaltrialsinGRapplication. Acomprehensive literaturesearchwasperformedusingEBSCOhost,ScienceDirect,SpringerLink,andMedline&Ovid databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) collagen OR sca?old OR hybrid sca?old OR biomaterial AND (2) gingiva recession OR tissue regeneration OR dental tissue OR healing mechanism OR gingiva. Only articles published from 2015 onwards were selected for further analysis. ThisreviewincludesthephysicochemicalpropertiesofColsca?oldandtheoutcomeforGR. The comprehensive literature search retrieved a total of 3077 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 15 articles were chosen for further review. The results from these articles indicated that Col promoted gingival tissue regeneration for GR healing. Therefore, this systematic review recapitulated that Col enhances regeneration of gingival tissue either through a slow or rapid process with no sign of cytotoxicity or adverse e?ect.
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