| Abstrak/Abstract |
Objective: The purpose of this study was to determine the effect of nanoencapsulated
Centella asiatica and Zingiber officinale extract, with the dose
of 3000 mg/day, in reducing cellulite and improving the composition of
subcutaneous adipose. Methods: This study used the quasi-experimental
with pre and post-controlled design using 38 female subjects who suffer
cellulite and have BMI > 25, and met the inclusion and exclusion criteria.
Subjects were grouped randomly into the 28-day treatment group, the
42-day treatment group, and control group. Subjects in the treatment
groups received the tested herbal with 3000 mg/day (2 x 3 capsules @500 mg)
that should be taken in determined duration. Appearance of cellulite and
lipid profile were observed and body composition analysis was performed
before and after treatment. Data were analyzed using T-test, Wilcoxon or
Mann-Whitney, while the comparison of the three treatment groups was
tested with ANOVA with 95% confidence level (p <0.05). Results: The
administration of the drug for 28 days can significantly repair the cellulite
grade. There was a significant improvement in cholesterol/HDL ratio, which
showed that the 28-day treatment group was better than the 42-day treatment
group. Compared to control group, the 28-day and the 42-day treatment groups showed better clinical improvements in total cholesterol, LDL, the
ratio of LDL/HDL, fasting blood sugar, weight, BMI, body fat, body fat
percentage, left and right arm fat, trunk fat, left thigh fat, and cellulite grade.
Conclusion: Nanoencapsulated extract of C. asiatica and Z. officinale can
improve cellulite, lipid profile, and subcutaneous fat. |
